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Why medicine industry likes to use cryogenic reaction vessel

By GCM September 28th, 2023 90 views
A deep-cold reaction vessel is a type of reactor used to produce high-purity pharmaceutical intermediates, characterized by the ability to conduct reactions at extremely low temperatures, typically below -100 ℃, with the use of liquid nitrogen or other cooling agents. The main advantages of the deep-cold reaction vessel are as follows:
Control reaction rate: The cryogenic reactor can effectively control the reaction rate, allowing the reaction to be carried out under gentler conditions, thereby reducing the generation of side reactions and unnecessary by-products. This is particularly important in the synthesis of pharmaceutical intermediates because many steps require precise control of reaction conditions to obtain high-purity intermediate products.

Avoid side reactions: The low-temperature environment of the deep-cold reaction vessel can avoid certain side reactions that may occur at room temperature, such as the hydrolysis of esterification reactions. At the same time, the low-temperature environment also helps to protect the reactants from oxidation or degradation and, thereby, improves the selectivity and yield of the reaction.

Reduce cleaning costs: The deep-cold reaction vessel can avoid the deposition of reactants and other substances on the vessel's mouth and other surfaces, which can adhere to the pipes and surfaces surrounding the hot-cold circulating cooling agents. Cooling the reaction vessel to a deep-cold temperature, where its temperature is lower than the precipitation cold point, can allow the precipitation to form and solidify as a priority, significantly reducing the cost of cleaning the internal of the reactor.

Improving purity: Products prepared using a deep-cold reaction vessel typically have much higher purity than those prepared using conventional methods. The use of a deep-cold reaction environment can avoid many of the side reactions and impurities that can occur in conventional reactors, thereby obtaining higher-purity products, which is of great practical significance for the preparation of pharmaceutical intermediates.
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